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Signal Transduction: Principles, Pathways, and ProcessesFrom Cold Spring Harbor Laboratory Press
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Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex network of signal transduction pathways within the cell ensures that these signals are relayed to the correct molecular targets and that the cell responds appropriately.
This textbook provides a comprehensive view of signal transduction, covering both the fundamental mechanisms involved and their roles in key biological processes. Taking a novel approach, it first lays out the basic principles of signal transduction, explaining how different receptors receive information and transmit it via signaling proteins, ions, and second messengers. It then surveys the major signaling pathways that operate in cells, before examining in detail how these function in processes such as cell growth and division, cell movement, metabolism, development, reproduction, the nervous system, and immune function.
The book is essential reading for students learning about signal transduction for the first time. It will also be a vital reference for all cell, molecular, and developmental biologists and pharmacologists, neurobiologists, and immunologists studying processes regulated by cell signaling.
- Sales Rank: #127698 in Books
- Published on: 2014-05-31
- Original language: English
- Number of items: 1
- Dimensions: 8.80" h x 1.10" w x 11.10" l, 3.40 pounds
- Binding: Hardcover
- 452 pages
Review
"...the editors recruited the most distinguished scientists in special areas as coauthors. Through the contributions of about 60 individual authors, a book developed, which covers not only the state of the art of signal transduction, but a volume that can serve as a source of knowledge and stimulating inspiration for interested students and investigators."
- The Quarterly Review of Biology
"...a one-stop shop for signaling information....it excels in providing information on just about any aspect of signal transduction imaginable...written by a veritable who's who of the signaling field...it is a magnum opus and should be a reference source..."
- Science Signaling
"The comprehensive nature of this superb textbook, as well as its careful and lucid writing, clear illustrations, and extensive references, makes it a must read for graduate students and research personnel."
- Choice
"I give this book an excellent review, with regard to its clear explanations and use of diagramming to illustrate cell communication."
- Olive Branch United Blog
Most helpful customer reviews
2 of 2 people found the following review helpful.
It is easy for both the author and the reader to become ...
By Amazon Customer
There are few and far books in between to act as a reference for the science of cellular signal transduction, primarily because it is, somewhat, a new science. A reference for signal transduction is prone to become a pedantic, collation of incomprehensive trivia, authors and editors generally finding it difficult to depart from its biochemical origins. This difficulty is primarily stems from the broadness of its subject matter which reaches from biochemical interactions, genetic codes and motifs, molecular dynamics, systems biology and network theory. It is easy for both the author and the reader to become myopic, focusing on only one aspect of this broad description of the most dynamic aspect of biological functions.
One of the best books out there that first presented a cohesive science of signal transduction was Cellular Signal Processing, edited by Friedrich Marks et al, and published in 2009. Marks had succeeded where others had failed by primarily focusing on the motifs of signaling proteins, how domains of a molecule affect the function of the pathway and through sharing these motifs they can be presumed to be genealogically associated with others, all the while presenting introductions to more specialized fields of networking, sacrificing voluminous myriad of details in lieu of a broader picture. Unfortunately his book is now already five years old.
Fewer books have since been able to present a reference that is unifying in its scope, while also presenting a detailed professional approach to its subject. Thankfully, Cold Spring Harbor Laboratory Press has again collected the leading minds of the field under a unified direction in an attempt to provide the next best thing. Concisely, Signal Transduction, edited by Cantley et al, succeeds in many places Cellular Signal Processing, edited by Marks et al, fails, and also fails in some noticeable points. For one thing, it is comprehensive and authoritative. It is indeed presented by the leading figures in the field, and its quality is on par to become staples of the researcher’s shelf like other books from its publisher. However, at times it does fall prey to the shortcomings of its field, as in section II where pages and pages are followed by the most up-to-date version of pathways after pathways. The important thing to understand when looking for a book on signaling pathways, or other cutting edge science for that matter, is to understand that within five years these descriptions will become obsolete, whereas a philosophy behind these pathways would at least last a decade.
Unfortunately, the researcher can seldom wait that long for someone to make sense for them, and we must carry on with what we have. In this sense, Signal Transduction is probably the best concise guide to the complex web of cellular signaling that is up to date
0 of 0 people found the following review helpful.
Great Book.
By B. Wolinsky
Signal Transduction is all about the role of communication within the body’s cellular structure, and how the cells respond collectively to nerve stimuli. These can be internal (such as with hormones or increased fat consumption) or external (such as inhaled gases) and the cells will all react differently. The book begins by listing and describing the roles of the different cell receptors, with their benefits and drawbacks clearly defined. The Tyrosine-Kinase receptor, for instance, stimulates cell proliferation, but if it becomes overactive, it can encourage uncontrolled cell division with is, to the layman, a tumor.
The next, and probably the most important part of a textbook like this, is the illustration. Take the chapter titled “Signaling and Cell Polarity” as an example; it uses a diagram to show the Hippo Pathway, and the connection between the proteins and other factors. The chapter on Sensory Receptors discusses things like photoreceptors, which play a role in vision. As we can all guess, any interruption between those receptors would result in impaired vision, so the diagrams show the capacity to process, store, and if the signals are not needed, dispose and discard. Another diagram shows the difference in receptor response to plant colors in bees versus primates. It shows how the photoreceptors of these animals respond differently to colors with regard to feeding.
Signal Transduction goes further into the subject of cellular communication, including reproduction. In this chapter, we learn how hormones can dictate sperm cell count, heart rate, and blood pressure. However, the authors don’t blame the problems entirely on the internal factors alone. They also discuss how external factors effect cell behavior, such as temperature, day and time, nutrition, etc. We know that gland such as the pituitary can be shut down by physical trauma, and if the pituitary gland doesn’t provide hormone, it can cause cells to become idle.
I give this book an excellent review, with regard to its clear explanations and use of diagramming to illustrate cell communication. I would, however, welcome some case studies of the symptoms of negative effects. The chapter where the photoreceptors are discussed would have been well-served with some photographic examples.
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